System Microbiology & Antimicrobial Resistance @Tun (SMART) Lab
Faculty of Medicine, The Chinese University of Hong Kong

Year 2023

1. Yang X, Zhang M, Zhang Y, Wei H, Guan Q, Dong C, Deng S, Tun HM, Xia Y. Ecological change of the gut microbiota during pregnancy and progression to dyslipidemia. NPJ Biofilms Microbiomes. 2023 Apr 3;9(1):14. doi: 10.1038/s41522-023-00383-7. PMID: 37012285; PMCID: PMC10070613.

​

2. Xu Z, Mak JWY, Lin Y, Yang K, Liu Q, Zhang F, Lau L, Tang W, Ching JY, Tun HM, Chan P, Chan FKL, Ng SC. Mixed-donor faecal microbiota transplantation was associated with increased butyrate-producing bacteria for obesity. Gut. 2023 Mar 31:gutjnl-2022-328993. doi: 10.1136/gutjnl-2022-328993. Epub ahead of print. PMID: 37001978.

​

3. Ariyawansa S, Gunawardana KN, Hapudeniya MM, Manelgamage NJ, Karunarathne CR, Madalagama RP, Ubeyratne KH, Wickramasinghe D, Tun HM, Wu P, Lam TTY, Chan OSK. One Health Surveillance of Antimicrobial Use and Resistance: Challenges and Successes of Implementing Surveillance Programs in Sri Lanka. Antibiotics (Basel). 2023 Feb 23;12(3):446. doi: 10.3390/antibiotics12030446. PMID: 36978313; PMCID: PMC10044479.

​

4. Kim JE, Tun HM, Bennett DC, Leung FC, Cheng KM. Microbial diversity and metabolic function in duodenum, jejunum and ileum of emu (Dromaius novaehollandiae). Sci Rep. 2023 Mar 18;13(1):4488. doi: 10.1038/s41598-023-31684-8. PMID: 36934111; PMCID: PMC10024708.

​

5. Peng Y, Chiu ATG, Li VWY, Zhang X, Yeung WL, Chan SHS, Tun HM. The role of the gut-microbiome-brain axis in metabolic remodeling amongst children with cerebral palsy and epilepsy. Front Neurol. 2023 Feb 27;14:1109469. doi: 10.3389/fneur.2023.1109469. PMID: 36923492; PMCID: PMC10009533.

​

6. Chen YY, Tun HM, Field CJ, Mandhane PJ, Moraes TJ, Simons E, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL. Impact of Cesarean Delivery and Breastfeeding on Secretory Immunoglobulin A in the Infant Gut Is Mediated by Gut Microbiota and Metabolites. Metabolites. 2023 Jan 18;13(2):148. doi: 10.3390/metabo13020148. PMID: 36837767; PMCID: PMC9959734.

​

7. Zhao X, Bridgman SL, Drall KM, Tun HM, Mandhane PJ, Moraes TJ, Simons E, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL. Infant Vitamin D Supplements, Fecal Microbiota and Their Metabolites at 3 Months of Age in the CHILD Study Cohort. Biomolecules. 2023 Jan 19;13(2):200. doi: 10.3390/biom13020200. PMID: 36830570; PMCID: PMC9952978.

​

8. Buchholz V, Bridgman SL, Nielsen CC, Gascon M, Tun HM, Simons E, Turvey SE, Subbarao P, Takaro TK, Brook JR, Scott JA, Mandhane PJ, Kozyrskyj AL. Natural Green Spaces, Sensitization to Allergens, and the Role of Gut Microbiota during Infancy. mSystems. 2023 Feb 15:e0119022. doi: 10.1128/msystems.01190-22. Epub ahead of print. PMID: 36790181.

​

9. Su Q, Tun HM, Liu Q, Yeoh YK, Mak JWY, Chan FK, Ng SC. Gut microbiome signatures reflect different subtypes of irritable bowel syndrome. Gut Microbes. 2023 Jan-Dec;15(1):2157697. doi: 10.1080/19490976.2022.2157697. PMID: 36573834; PMCID: PMC9809927.

​

​

Year 2022

1. Tun HM, Sanyal S. Proteomics-based approach for target discovery in Zika virus infection: abridged secondary publication. Hong Kong Med J. 2022 Dec;28 Suppl 6(6):29-32. PMID: 36535796.

​

2. Liang S, Sin ZY, Yu J, Zhao S, Xi Z, Bruzzone R, Tun HM. Multi-cohort analysis of depression-associated gut bacteria sheds insight on bacterial biomarkers across populations. Cell Mol Life Sci. 2022 Dec 10;80(1):9. doi: 10.1007/s00018-022-04650-2. PMID: 36495344.

​

3. Luo Y, Lv H, Zhao S, Sun Y, Liu C, Chen C, Liang W, Kwok KO, Teo QW, So RT, Lin Y, Deng Y, Li B, Dai Z, Zhu J, Zhang D, Fernando J, Wu NC, Tun HM, Bruzzone R, Mok CK, Mu X. Age-related seroprevalence trajectories of seasonal coronaviruses in children including neonates in Guangzhou, China. Int J Infect Dis. 2023 Feb;127:26-32. doi: 10.1016/j.ijid.2022.11.044. Epub 2022 Dec 5. PMID: 36481488; PMCID: PMC9721286. 

​

4. Su Q, Liu Q, Lau RI, Zhang J, Xu Z, Yeoh YK, Leung TWH, Tang W, Zhang L, Liang JQY, Yau YK, Zheng J, Liu C, Zhang M, Cheung CP, Ching JYL, Tun HM, Yu J, Chan FKL, Ng SC. Faecal microbiome-based machine learning for multi-class disease diagnosis. Nat Commun. 2022 Nov 10;13(1):6818. doi: 10.1038/s41467-022-34405-3. PMID: 36357393; PMCID: PMC9649010.

​

5. Liu Q, Su Q, Zhang F, Tun HM, Mak JWY, Lui GC, Ng SSS, Ching JYL, Li A, Lu W, Liu C, Cheung CP, Hui DSC, Chan PKS, Chan FKL, Ng SC. Multi-kingdom gut microbiota analyses define COVID-19 severity and post-acute COVID-19 syndrome. Nat Commun. 2022 Nov 10;13(1):6806. doi: 10.1038/s41467-022-34535-8. PMID: 36357381; PMCID: PMC9648868.

​

6. Chan OSK, Lam WWT, Fukuda K, Tun HM, Ohmagari N, Littmann J, Zhou XD, Xiao Y, Liu P, Wernli D. Antimicrobial Resistance Policy Protagonists and Processes-A Qualitative Study of Policy Advocacy and Implementation. Antibiotics (Basel). 2022 Oct 18;11(10):1434. doi: 10.3390/antibiotics11101434. PMID: 36290091; PMCID: PMC9598113.

​

7. Chan OSK, Baranger-Ete M, Lam WWT, Wu P, Yeung M, Lee E, Bond H, Swan O, Tun HM. A Retrospective Study of Antimicrobial Resistant Bacteria Associated with Feline and Canine Urinary Tract Infection in Hong Kong SAR, China-A Case Study on Implication of First-Line Antibiotics Use. Antibiotics (Basel). 2022 Aug 23;11(9):1140. doi: 10.3390/antibiotics11091140. PMID: 36139920; PMCID: PMC9495203.

​

8. Huang Y, Liu J, Tun HM, Stanton C, Chen T, El-Nezami H, Wei H, Wang M, Wu Q. Gut microbiota insights into human adaption to high-plateau diet. Imeta. 2022 Mar;1(1):e6. doi: 10.1002/imt2.6. Epub 2022 Feb 24. PMID: 35989883; PMCID: PMC9387673.

​

9. Xiao T, Zhang D, Tun HM, Shah NP. Cysteine protected cells from H2O2-induced damage and promoted long-chain fatty acids synthesis in vivo to improve γ-aminobutyric acid production in Levilactobacillus brevis. World J Microbiol Biotechnol. 2022 Aug 16;38(11):185. doi: 10.1007/s11274-022-03379-1. PMID: 35972565.

​

10. Chan OS, Tun HM, Uchea C, Wu P, Fukuda K. What and where should the next antimicrobial resistance policies focus on? J Glob Antimicrob Resist. 2022 Dec;31:149-151. doi: 10.1016/j.jgar.2022.08.003. Epub 2022 Aug 7. PMID: 35948243; PMCID: PMC9357450.

​

11. Obiakor CV, Parks J, Takaro TK, Tun HM, Morales-Lizcano N, Azad MB, Mandhane PJ, Moraes TJ, Simons E, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL. Early Life Antimicrobial Exposure: Impact on Clostridioides difficile Colonization in Infants. Antibiotics (Basel). 2022 Jul 21;11(7):981. doi: 10.3390/antibiotics11070981. PMID: 35884235; PMCID: PMC9311587.

​

12. Chan CL, Wai HK, Wu P, Lai SW, Chan OS, Tun HM. A Universal LC-MS/MS Method for Simultaneous Detection of Antibiotic Residues in Animal and Environmental Samples. Antibiotics (Basel). 2022 Jun 24;11(7):845. doi: 10.3390/antibiotics11070845. PMID: 35884099; PMCID: PMC9311993.

​

13. Peng Y, Sin DZY, Tun HM. International travel, the gut microbiome, and ESBL-E coli carriage. Lancet Microbe. 2022 Oct;3(10):e730. doi: 10.1016/S2666-5247(22)00201-4. Epub 2022 Jul 21. PMID: 35871796.

​

14. Zheng X, Li S, Deng Y, Xu X, Ding J, Lau FTK, In Yau C, Poon LLM, Tun HM, Zhang T. Quantification of SARS-CoV-2 RNA in wastewater treatment plants mirrors the pandemic trend in Hong Kong. Sci Total Environ. 2022 Oct 20;844:157121. doi: 10.1016/j.scitotenv.2022.157121. Epub 2022 Jul 2. PMID: 35787900; PMCID: PMC9249664.

​

15. Chan OSK, Wernli D, Liu P, Tun HM, Fukuda K, Lam W, Xiao Y, Zhou X, Grépin KA. Unpacking multi-level governance of antimicrobial resistance policies: the case of Guangdong, China. Health Policy Plan. 2022 Oct 12;37(9):1148-1157. doi: 10.1093/heapol/czac052. PMID: 35775460; PMCID: PMC9558914.

​

16. Xu X, Deng Y, Zheng X, Li S, Ding J, Yang Y, On HY, Yang R, Chui HK, Yau CI, Tun HM, Chin AWH, Poon LLM, Peiris M, Leung GM, Zhang T. Evaluation of RT-qPCR Primer-Probe Sets to Inform Public Health Interventions Based on COVID-19 Sewage Tests. Environ Sci Technol. 2022 Jun 21;56(12):8875-8884. doi: 10.1021/acs.est.2c00974. Epub 2022 May 18. PMID: 35584232; PMCID: PMC9128008.

​

17. Jitmitsumphan S, Sripetdee T, Chaimueangchuen T, Tun HM, Chinkanjanarot S, Klomkliang N, Srinives S, Jonglertjunya W, Ling TC, Phadungbut P. Unveiling the Molecular Origin of Vapor-Liquid Phase Transition of Bulk and Confined Fluids. Molecules. 2022 Apr 20;27(9):2656. doi: 10.3390/molecules27092656. PMID: 35566010; PMCID: PMC9103202.

​

18. Deng Y, Zheng X, Xu X, Chui HK, Lai WK, Li S, Tun HM, Poon LLM, Ding J, Peiris M, Leung GM, Zhang T. Use of Sewage Surveillance for COVID-19: A Large-Scale Evidence-Based Program in Hong Kong. Environ Health Perspect. 2022 May;130(5):57008. doi: 10.1289/EHP9966. Epub 2022 May 12. PMID: 35549717; PMCID: PMC9097955.

​

19. Zhang S, Tun HM, Zhang D, Chau HT, Huang FY, Kwok H, Wong DK, Mak LY, Yuen MF, Seto WK. Alleviation of Hepatic Steatosis: Dithizone-Related Gut Microbiome Restoration During Paneth Cell Dysfunction. Front Microbiol. 2022 Feb 25;13:813783. doi: 10.3389/fmicb.2022.813783. PMID: 35283810; PMCID: PMC8914291.

​

20. Ng SC, Peng Y, Zhang L, Mok CK, Zhao S, Li A, Ching JY, Liu Y, Yan S, Chan DLS, Zhu J, Chen C, Fung AC, Wong KK, Hui DS, Chan FK, Tun HM. Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events. Gut. 2022 Jun;71(6):1106-1116. doi: 10.1136/gutjnl-2021-326563. Epub 2022 Feb 9. PMID: 35140064; PMCID: PMC8844967.

​

21. Zheng X, Deng Y, Xu X, Li S, Zhang Y, Ding J, On HY, Lai JCC, In Yau C, Chin AWH, Poon LLM, Tun HM, Zhang T. Comparison of virus concentration methods and RNA extraction methods for SARS-CoV-2 wastewater surveillance. Sci Total Environ. 2022 Jun 10;824:153687. doi: 10.1016/j.scitotenv.2022.153687. Epub 2022 Feb 5. PMID: 35134418; PMCID: PMC8816846.

​

​

Year 2021

​

1. Chan OSK, Naing T, Tun HM. Upholding veterinary services as a pillar of one health in Myanmar. One Health. 2021 Sep 16;13:100329. doi: 10.1016/j.onehlt.2021.100329. PMID: 34604492; PMCID: PMC8473542.

​

2. Chen YY, Zhao X, Moeder W, Tun HM, Simons E, Mandhane PJ, Moraes TJ, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL. Impact of Maternal Intrapartum Antibiotics, and Caesarean Section with and without Labour on Bifidobacterium and Other Infant Gut Microbiota. Microorganisms. 2021 Aug 31;9(9):1847. doi: 10.3390/microorganisms9091847. PMID: 34576741; PMCID: PMC8467529. 

​

3. Chan OSK, Bradley KCF, Grioni A, Lau SKP, Li WT, Magouras I, Naing T, Padula A, To EMW, Tun HM, Tutt C, Woo PCY, Bloch R, Mauroo NF. Veterinary Experiences can Inform One Health Strategies for Animal Coronaviruses. Ecohealth. 2021 Sep;18(3):301-314. doi: 10.1007/s10393-021-01545-9. Epub 2021 Sep 20. PMID: 34542794; PMCID: PMC8450722.

​

4. Zhang D, Peng Y, Chan C-L, On H, Wai HK-F, Shekhawat SS, Gupta AB, Varshney AK, Chuanchuen R, Zhou X, Xia Y, Liang S, Fukuda K, Medicherla KM and Tun HM (2021) Metagenomic Survey Reveals More Diverse and Abundant Antibiotic Resistance Genes in Municipal Wastewater Than Hospital Wastewater. Front. Microbiol. 12:712843. doi: 10.3389/fmicb.2021.712843

​

5. Rodriguez, N., Tun, H. M., Field, C. J., Mandhane, P. J., Scott, J. A., & Kozyrskyj, A. L. (2021). Prenatal Depression, Breastfeeding, and Infant Gut Microbiota [Perspective]. Frontiers in Microbiology, 12(1984). https://doi.org/10.3389/fmicb.2021.664257

​

6. Orsso, C.E.; Peng, Y.; Deehan, E.C.; Tan, Q.; Field, C.J.; Madsen, K.L.; Walter, J.; Prado, C.M.; Tun, H.M.; Haqq, A.M. Composition and Functions of the Gut Microbiome in Pediatric Obesity: Relationships with Markers of Insulin Resistance. Microorganisms 2021, 9, 1490. https://doi.org/10.3390/microorganisms9071490

​

7. Tan Q, Orsso CE, Deehan EC, Kung JY, Tun HM, Wine E, Madsen KL, Zwaigenbaum L, Haqq AM. Probiotics, prebiotics, synbiotics, and fecal microbiota transplantation in the treatment of behavioral symptoms of autism spectrum disorder: A systematic review. Autism Res. 2021 Jun 26. doi: 10.1002/aur.2560. Epub ahead of print. PMID: 34173726.

​

8. Xu X, Zheng X, Li S, Lam NS, Wang Y, Chu DKW, Poon LLM, Tun HM, Peiris M, Deng Y, Leung GM, Zhang T. The first case study of wastewater-based epidemiology of COVID-19 in Hong Kong. Sci Total Environ. 2021 May 24;790:148000. doi: 10.1016/j.scitotenv.2021.148000. Epub ahead of print. PMID: 34091338; PMCID: PMC8142803.

​

9. Manikam L, Bou Karim Y, Boo YY, Allaham S, Marwaha R, Parikh P, Lakhanpaul M; Childhood Infections and Pollution Consortium. Operationalising a One Health approach to reduce the infection and antimicrobial resistance (AMR) burden in under-5 year old urban slum dwellers: The Childhood Infections and Pollution (CHIP) Consortium. One Health. 2020 May 27;10:100144. doi: 10.1016/j.onehlt.2020.100144. PMID: 32518814; PMCID: PMC7272496.

​

10. Suwannarong K, Janetanakit T, Kanthawee P, Suwannarong K, Theamboonlers A, Poovorawan Y, Tun HM, Chanabun S, Amonsin A. Coronavirus seroprevalence among villagers exposed to bats in Thailand. Zoonoses Public Health. 2021 Aug;68(5):464-473. doi: 10.1111/zph.12833. Epub 2021 Apr 16. PMID: 33864357; PMCID: PMC8251071.

​

11. Tamana SK, Tun HM, Konya T, Chari RS, Field CJ, Guttman DS, Becker AB, Moraes TJ, Turvey SE, Subbarao P, Sears MR, Pei J, Scott JA, Mandhane PJ, Kozyrskyj AL. Bacteroides-dominant gut microbiome of late infancy is associated with enhanced neurodevelopment. Gut Microbes. 2021 Jan-Dec;13(1):1-17. doi: 10.1080/19490976.2021.1930875. PMID: 34132157.

​

12. Chen T, Qin Y, Chen M, Zhang Y, Wang X, Dong T, Chen G, Sun X, Lu T, White RA 3rd, Ye P, Tun HM, Xia Y. Gestational diabetes mellitus is associated with the neonatal gut microbiota and metabolome. BMC Med. 2021 May 27;19(1):120. doi: 10.1186/s12916-021-01991-w. PMID: 34039350.

​

13. Peng Y, Zhang D, Chen T, Xia Y, Wu P, Seto WK, Kozyrskyj AL, Cowling BJ, Zhao J, Tun HM. Gut microbiome and resistome changes during the first wave of the COVID-19 pandemic in comparison with pre-pandemic travel-related changes. J Travel Med. 2021 May 5:taab067. doi: 10.1093/jtm/taab067

​

14. Li, Y., Hou, G., Zhou, H., Wang Y., Tun, H., et al. Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery. Sig Transduct Target Ther 6, 155 (2021). https://doi.org/10.1038/s41392-021-00508-4

​

15. Zhong, H., Wang, Y., Shi, Z., Zhang, L., Ren, H., He, W., Zhang, Z., Zhu, A., Zhao, J., Xiao, F., Yang, F., Liang, T., Ye, F., Zhong, B., Ruan, S., Gan, M., Zhu, J., Li, F., Li, F., Wang, D., … Zhao, J. (2021). Characterization of respiratory microbial dysbiosis in hospitalized COVID-19 patients. Cell discovery, 7(1), 23. https://doi.org/10.1038/s41421-021-00257-2

​

16. Tun HM, Peng Y, Chen B, Konya TB, Morales-Lizcano NP, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Moraes TJ, Sears MR, Turvey SE, Subbarao P, Simons E, Scott JA, Kozyrskyj AL. Ethnicity associations with food sensitization are mediated by gut microbiota development in the first year of life. Gastroenterology. 2021 Mar 16:S0016-5085(21)00523-0. doi: 10.1053/j.gastro.2021.03.016. Epub ahead of print. PMID: 33741316.

​

17. Peng, Y., Liang, S., Poonsuk, K., On, H., Li, S. W., Maurin, M., Chan, C. H., Chan, C. L., Sin, Z. Y., & Tun, H. M. (2021). Role of gut microbiota in travel-related acquisition of extended spectrum β-lactamase-producing Enterobacteriaceae. Journal of travel medicine, taab022. Advance online publication. https://doi.org/10.1093/jtm/taab022

​

18. Deehan, E. C., Colin-Ramirez, E., Triador, L., Madsen, K. L., Prado, C. M., Field, C. J., Ball, G., Tan, Q., Orsso, C., Dinu, I., Pakseresht, M., Rubin, D., Sharma, A. M., Tun, H., Walter, J., Newgard, C. B., Freemark, M., Wine, E., & Haqq, A. M. (2021). Efficacy of metformin and fermentable fiber combination therapy in adolescents with severe obesity and insulin resistance: study protocol for a double-blind randomized controlled trial. Trials, 22(1), 148. https://doi.org/10.1186/s13063-021-05060-8

​

​

Year 2020

​

1. Sobko, T., Liang, S., Cheng, W.H.G. et al. Impact of outdoor nature-related activities on gut microbiota, fecal serotonin, and perceived stress in preschool children: the Play&Grow randomized controlled trial. Sci Rep 10, 21993 (2020). doi: 10.1038/s41598-020-78642-2

​

2. Vu K, Lou W, Tun HM, Konya TB, Morales-Lizcano N, Chari RS, Field CJ, Guttman DS, Mandal R, Wishart DS, Azad MB, Becker AB, Mandhane PJ, Moraes TJ, Lefebvre DL, Sears MR, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL. 2020. From birth to overweight and atopic disease: multiple and common pathways of the infant gut microbiome. Gastroenterology. doi: 10.1053/j.gastro.2020.08.053.

​

3. Peng Y, Zhao J, Tun HM. 2020. The New Foe and Old Friends: Are We Ready for Microbiota-based Therapeutics in Treating COVID-19 Patients? Gastroenterology. doi: 10.1053/j.gastro.2020.08.048.

​

4. Kelsea M. Drall, Catherine J. Field, Andrea M. Haqq, Russell J. de Souza, Hein M. Tun, Nadia P. Morales-Lizcano, Theodore B. Konya, David S. Guttman, Meghan B. Azad, Allan B. Becker, Diana L. Lefebvre, Piush J. Mandhane, Theo J. Moraes, Malcolm R. Sears, Stuart E. Turvey, Padmaja Subbarao, James A. Scott, Anita L Kozyrskyj. 2020. Vitamin D supplementation in pregnancy and early infancy in relation to gut microbiota composition and C. difficile colonization: implications for viral respiratory infections. Gut Microbes. doi:10.1080/19490976.2020.1799734

​

5. Ye Peng, Qiming Tan, Shima Afhami, Edward C. Deehan, Suisha LiangMarie Gantz, Lucila Triador, Karen L. Madsen, Jens Walter, Hein M. Tun, Andrea M. Haqq. 2020. The Gut Microbiota Profile in Children with Prader–Willi Syndrome. Genes. doi:10.3390/genes11080904

​

6. Charlene C Nielsen, Mireia Gascon, Alvaro R Osornio-Vargas, Catherine Shier, David S Guttman, Allan B Becker, Meghan B Azad, Malcolm R Sears, Diana L Lefebvre, Theo J Moraes, Stuart E Turvey, Padmaja Subbarao, Tim K Takaro, Jeffrey R Brook, James A Scott, Piush J Mandhane1, Hein M Tun*, Anita L Kozyrskyj*. Natural environments in the urban context and gut microbiota in infants. Environ Int . 2020 Sep;142:105881. doi: 10.1016/j.envint.2020.105881.

​

7. Hein M Tun, Shucong Li, Ilkyu Yoon, Sarah J Meale, Paula A Azevedo, Ehsan Khafipour, Jan C Plaizier. Saccharomyces cerevisiae fermentation products (SCFP) stabilize the ruminal microbiota of lactating dairy cows during periods of a depressed rumen pH. BMC Vet Res . 2020 Jul 11;16(1):237. doi: 10.1186/s12917-020-02437-w.

​

8. Zhang, M., Wang, X., Yang, X., Dong, T., Hu, W., Guan, Q., … Xia, Y. (2020). Increased risk of gestational diabetes mellitus in women with higher prepregnancy ambient PM2.5 exposure. Science of The Total Environment, 138982. doi:10.1016/j.scitotenv.2020.138982

​

​

Year 2019

 

1. Tun HM and Bruzzone R. 2019. Early-life antibiotic exposure, gut microbiome, and colonization resistance. J Health Sci Altern Med. 1(3):1-5.

       Invited Editorial

 

2. Drall KM, Tun HM, Morales-lizcano N, Konya TB, Guttman DS, Field CJ, Mandal R, Wishart DS, Becker AB, Azad MB, Lefebvre DL, Mandhane PJ, Moraes TJ, Sears MR, Turvey SE, Subbarao P, Scott JA, Kozyrskyj A. 2019. Clostrdioides difficile colonization is differentially associated with gut microbiome profiles by infant feeding modality at 3 months of age. Front Immunol. doi: 10.3389/fimmu.2019.02866.

 

3. Tan Q, Orsso CE, Deehan EC, Triador L, Field CJ, Tun HM, Han JC, Muller TD, Haqq AM. 2019. Current and emerging therapies for managing hyperphagia and obesity in Prader-Willi syndrome: A narrative review. Obes Reviews. doi: 10.1111/obr.12992.

 

​

Year 2018

 

1. Drall KM, Tun HM, Kozyrskyj AL. 2018. Commentary: The influence of proton pump inhibitors on the fecal microbiome of infants with gastroesophageal reflux-a prospective longitudinal interventional study. Front Cell Infect Microbiol. 8:430.

 

2. Tun HM, Mahoney JJ, Konya TB, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Brook JR, Lou W, Takaro TK, Scott JA, Kozyrskyj AL, CHILD Study Investigators. 2018. Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children. CMAJ. 190(37):E1097-E1107. [Featured in CNN, USA Today etc. Most popular paper in 2018 by CMAJ with an Altmetric score of 1224.  Editors’ choice for Podcast.]

 

3. Zhang Z, Tun HM, Li R, Gonzalez BJM, Keenes HC, Nyachoti CM, Kiarie E, Khafipour E. 2018. Impact of xylanases on gut microbiota of growing pigs fed corn- or wheat-based diets. Anim Nutr. 4(4):339-350.

 

4. Obiakor VC, Tun HM, Bridgman SL, Arrieta M, Kozyrskyj AL. 2018. The association between early life antibiotic use and allergic disease in young children: recent insights and their implications. Expert Rev Clin Immunol. 14(10):841-855.

 

5. Ho NT, Li F, Lee-Sarwar KA, Tun HM, Brown BP, Pannaraj PS, Bender JM, Azad MB, Thompon AL, Weiss ST, Azcarate-Peril MA, Litonjua AA, Kozyrskyj AL, Jaspan HB, Aldrovandi GM, Kuhn L. 2018. Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations. Nat Commun. 9(1):4169.

 

6. Forbes JD, Azad MB, Vehling L, Tun HM, Konya TB, Guttman DS, Field CJ, Lefebvre D, Sears MR, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Subbarao P, Scott JA, Kozyrskyj AL. 2018. Association of Exposure to Formula in hospital and subsequent infant feeding practices with gut microbiota and overweight risk in the first year of life. JAMA Pediatr. 172(7):e181161. Featured in CNN, Physician’s Briefing etc. Editors’ choice for iTune Podcast- July 2018. Highly Cited Paper in the field of Clinical Medicine.

 

7. Ndou SP, Tun HM, Kiarie E, Walsh MC, Khafipour E, Nyachoti CM. 2018. Dietary supplementation with flaxseed meal and oat hulls modulates intestinal histomorphometric characteristics, digesta- and mucosa-associated microbiota in pigs. Sci Rep. 8(1):5880.

 

8. Tun HM, Bridgman SL, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL, the CHILD study investigators. 2018. Intergenerational transmission of overweight and obesity from mother to offspring: roles of birth mode and infant gut microbiota. JAMA Pediatr. 172(4):368-377. [Featured in New York Time, Science Daily, Physician’s Briefing etc. Editors’ choice for iTune Podcast- April 2018. One of the top 5 news stories of the year 2018, FoMD, U of Alberta. Highly Cited Paper in the field of Clinical Medicine.]

 

9. Liu S*, Tun HM*, Leung FC, Bennett DC, Zhang H, Cheng KM. 2018. Interaction of genotype and diet on small intestine microbiota of Japanese quail fed a cholesterol enriched diet. Sci Rep. 8(1):2381

 

​

Year 2017

 

1. Koleva PT, Tun HM, Shestopaloff K, Konya T, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, CHILD Study Investigators, Scott JA, Kozyrskyj AL. 2017. Sex-specific impact of asthma during pregnancy on infant gut microbiota. Eur Respir J. 50(5):1700280.

 

2. Yasmin F, Tun HM, Dinu I, Azad MB, Konya T, Guttman DS, Field CJ, Chari RS, Sears MR, Subbarao P, Mandhane PJ, Turvey SE, Becker AB, Scott JA, Kozyrskyj AL and the CHILD Study Investigators. 2017. Caesarean section, formula feeding, and infant antibiotic exposure: separate and combined impacts on gut microbial changes in later infancy. Front Pediatr. 5:200.

 

3. Tun HM, Matenchuk BA, Kozyrskyj AL. 2017. Gut microbial-induced inflammation: normal aging or lifestyle changes? J Lab Precis Med. 2:48. Invited Editorial.

 

4. Liu R*, Tun HM*, Jahan M, Farenhorst A, Kumar A, Fernando DW, Khafipour E.  2017. Comparison of DNA-, PMA-, and RNA-based 16S rRNA illumina sequencing for detection of live bacteria in water. Sci Rep. 7:5752.

 

5. Zhao Q, Harbour SN, Kolde R, Latorre I, Tun HM, Schoeb TR, Moon J, Khafipour E, Xavier RJ, Weaver CT, Elson CO. 2017. Selective induction of homeostatic Th17 cells in the murine intestine by cholera toxin interacting with the microbiota. J Immunol. 199(1):312-322. This paper is featured by the “In This Issue” section of the journal, which highlights articles considered to be among the top 10% of articles published in the journal.

 

6. Tun HM, Konya T, Takaro TK, Brook JR, Chari R, Field CJ, Guttman D, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL and the CHILD Study Investigators. 2017. Exposure to household furry pets influences the gut microbiota of infant at 3-4 months following various birth scenarios. Microbiome. 5(1):40. The most popular microbiome paper of the year 2017 (by BMC and Microbiome Digest) with an Altmetric score of 931. Featured in TIME, Reuters, Reader’s Digest, USA Today, Science Daily etc. The paper was also highlighted in BMJ’s Veterinary Record. One of the top 5 news stories of the year 2017, FoMD, U of Alberta.

 

7. Wu Q, Tun HM, Law Y, Khafipour E, Shah NP. 2017. Common distribution of gad operon in Lactobacillus brevis and its GadA contributes to efficient GABA synthesis towards cytosolic near-neutral pH. Front Microbiol. 8:206.

 

8. Farenhorst A, Li R, Jahan M, Tun HM, Mi R, Mudiyansel IA, Kumar A, Khafipour E. 2017. Bacteria in drinking water sources of a first nation reserve in Canada. STOTEN. 575:813-819.

 

9. Plaizier JC, Li S, Tun HM, Khafipour E. 2017. Nutritional models of experimentally induced subacute ruminal acidosis (SARA) differ in their impact on rumen and hindgut bacterial communities in dairy cows. Front Microbiol. 7:2128.

 

​

Year 2016

 

1. Derakhshani H, Tun HM, Alqarni S, Cardoso FC, Plaizier JC, Khafipour E, Loor JJ. 2016. Linking peripartal dynamics of ruminal microbiota to dietary changes and production parameters. Front Microbiol. 7:2143.

 

2. Fernando D, Tun HM, Poole J, Patidar R, Li R, Mi R, Amarwansha G, Fernando D, Khafipour E, Farenhorst A, Kumar A. 2016. Detection of antibiotic resistance genes in source and drinking water samples from a first nation community in Canada. Applied Environ Microbiol. 82(15):4767-4775.

 

3. Khafipour E, Li S, Tun HM, Derakhshani H, Moosavi S, Plaizier JC. 2016. Effects of grain feeding on microbiota in the digestive tract of cattle. Animal Frontiers. 6(2): 13-19.

 

4. Zhang W, Hartmann R, Tun HM, Elson CO, Khafipour E, Garvey WT. 2016. Deletion of the Toll-like receptor 5 gene in mice does not determine the gut microbiome profile that induces metabolic syndrome: environment trumps genotype. PloS One. 11(3):e0150943.

 

5. Tun HM, Cai Z, Khafipour E. 2016. Monitoring the survivability and infectivity of porcine epidemic diarrhoea virus (PEDv) in infected on-farm earthen manure storages (EMS). Front Microbiol. 7:265.

 

6. Wang Y, Ames NP, Tun HM, Jones PJ, Khafipour E. 2016. High molecular weight β-glucan alters gut microbiota towards reduced cardiovascular disease risk. Front Microbiol.  7:129.

 

​

Year 2015

 

1. Ng J, Chan Y, Tun HM, Leung FC, Shin PKS, Chiu JMY. 2015. Pyrosequencing of the coral Platygyra carnosus reveals shift in bacterial community composition associated with skeletal tissue growth anomalies. Front Microbiol. 6:1142.

 

2. Liu S, Bennett DC, Tun HM, Kim J, Zhang H, Leung FC, Cheng KM. 2015. The effect of diet and host genotype on ceca microbiota of Japanese quail fed a cholesterol enriched diet. Front Microbiol. 6:1092.

 

3. Derakhshani H, Tun HM, Khafipour E. 2015. The impacts of extended single-indexing multiplexed 16S rRNA sequencing on taxonomic identification and diversity analysis. J Basic Microbiol. 56:321-326.

 

4. Lu WH*, Tun HM*, Sun BL, Mo JY, Zhou QF, Deng YX, Xie QM, Bi YZ, Leung FC, Ma JY. 2015. Re-emerging of porcine respiratory and reproductive syndrome virus (lineage 3) and increased pathogenicity after genomic recombination with vaccine variant. Vet Micro. 175(2-4):332-240.

 

​

Year 2014

 

1. Tun HM, Wisedchanwet T, Wongphatcharachai M, Nonthabenjawan N, Chaiyawong S, Theamboonlers A, Poovorawan Y, Amonsin A. 2014. Development of one-step reverse transcription loop-mediated isothermal amplification (LAMP) as a screening tool for influenza A viruses. TJVM. 44(4):427-434.

 

2. Ahad A, Thornton RN, Rabbani M, Yaqub T, Younus M, Muhammad K, Mahmood A, Shabbir MZ, Kashem MA, Islam MZ, Mangtani P, Dhand NK, Burgess GW, Tun HM, Hoque MA. 2014. Risk factors for H7 infection in commercial poultry farm workers in provinces within Pakistan. Prev Vet Med. 117(3-4):610-614.

 

3. Jiang J*, Tun HM*, Yuen CS, Leung FC. 2014. Complete Genome sequence of Klebsiella oxytoca HKOP isolated from Giant Panda Feces. BMC Res Notes. 7:827.

 

4. Hoque MA, Hassan MM, Haque ME, Shaikat AH, Khan SA, Alim A, Skerratt LF, Islam A, Tun HM, Dissanayake R, Day TK, Debnath NC, Yamage M. 2014. A survey on gastro-intestinal parasites in domestic and wild birds in different areas of Chittagong and Greater Sylhet, Bangladesh. Prev Vet Med. 117(1):305-312.

 

5. Ma AP, Jing J, Tun HM, Mauroo NF, Yuen CS, Leung FC. 2014. Complete genome sequence of Staphylococcus xylosus HKUOPL8, a potential opportunistic pathogen of mammals. Genome Announc. 2(4):e00653-14.

 

6.  Wu Q, Tun HM, Leung FC, Shah N. 2014. Genomic insights into high exopolysaccharide-producing dairy starter bacterium Streptococcus thermophiles ASCC 1275. Sci Rep. 4:4794.

 

7.  Park T, Ding W, Cheng S, Brar MS, Ma APY, Tun HM, Leung FC. 2014. Microbial community in microbial fuel cell (MFC) medium and effluent enriched with purple photosynthetic bacterium (Rhodopseudomonas sp.). AMB Express. 4:22.

​

8.  Tun HM, Mauroo NF, Yuen CS, Ho JCW, Wong MT, Leung FC. 2014. Microbial diversity and evidence of novel homoacetogens in the gut of giant panda (Ailuropoda melanoleuca). PloS One. 9(1):e79902.

​

​

Year 2013

 

1.  Hoque MA*, Tun HM*, Hassan MM, Khan SA, Islam MN, Giasuddin M, Osmani MG, Islam MA, Thornton RN, Burgess GW, Skerratt LF, Selleck P, Burn E, Debnath NC, Leung FC. 2013. Molecular epidemiology of Influenza A (H5N1) viruses, Bangladesh, 2007-2011. Prev Vet Med. 111:314-318.

​

2.  Bennett DC*, Tun HM*, Kim JE, Leung FC, Cheng KM. (2013) Characterization of cecal microbiota of the Emu (Dromaius novaehollandiae). Vet Microbiol. 166:304-310.

​

3.  Wong MT, Zhang D, Li J, Hui RK, Tun HM, Brar MS, Park T, Chen Y, Leung FC. 2013. Towards a metagenomic understanding on enhanced biomethane production from waste activated sludge after pH 10 pretreatment. Biotechnol Biofuels. 6:38.

​

Year 2012

 

4.  Islam SK, Alauddin M, Hassan MM, Khan SA, Alam MR, Hossain MB, Ahasan AS, Saifuddin AK, Sultana S, Tun HM, Shaikat AH, Debnath NC, Hoque MA. 2012. Biochemical analysis on blood and crop contents of household chickens along with their production and health status in Bangladesh. Pakistan Vet J. 32(4):575-578.

 

5.  Lam TT, Hon CC, Lemey P, Pybus OG, Shi M, Tun HM, Li J, Jiang J, Holmes EC, Leung FC. 2012. Phylodynamics of H5N1 avian influenza virus in Indonesia. Mol Ecol. 21(12):3062-77.

​

6. Tun HM, Brar MS, Khin N, Jun L, Hui RK, Dowd SE, Leung FC. 2012. Gene-centric metagenomics analysis of feline intestinal microbiome using 454 junior pyrosequencing. J Microbiol Methods. 88(3):369-76.

​

​

Year 2011

 

1. Tun HM, Shi M, Wong CL, Ayudhya SN, Amonsin A, Thanawongnuwech R, Leung FC. 2011. Genetic diversity and multiple introductions of porcine reproductive and respiratory syndrome viruses in Thailand. Virol J. 8:164.

​